The CMSB-NBIC Rosetta Resolver server

(last updated February 27th 2013)

Rosetta Resolver maintenance and support [top]

The CMSB-NBIC Rosetta Resolver system is maintained and administrated by the Leiden Genome Technology Center (LGTC) for the Centre for Medical Systems Biology (CMSB). The administrator team consists of:

and is assisted by Floris Jan Sicking (Leiden Institute for Advanced Computer Science (LIACS)), who contributes his expertise by monitoring Rosetta Resolver's Oracle database backup and configuration.

Each institute has their local coordinator who keeps in contact with the administrator team, authenticates new users from their institute and is the local expert on access and use of the system:

Rosetta Resolver licenses [top]

The CMSB-NBIC Rosetta Resolver system uses concurrent licenses to access the database. That means that the total number of users that can connect to the system at the same time is limited to the number of licenses issued to a specific user group. If you recurrently fail to login due to all accounts being used, please contact the database administrator.

Out of consideration for other users, please always log out of Rosetta when you are done working or taking a break!

Rosetta Resolver problem solving [top]

If you have a problem using Rosetta Resolver, please follow this route:

Getting access to the CMSB-NBIC Rosetta Resolver system (New users) [top]

New users are adviced to apply for a user account and to access Rosetta Resolver using a client computer in their departments/groups. To get acquainted with Rosetta Resolver, please follow the user training guide. Ask your local contact person about additional training possibilities.

In order to use Rosetta Resolver successfully in your department/group, the computer chosen to run the client software should: 

1) meet these requirements

2) be registered to get access to the Rosetta Resolver server. To register, please send an email with the IP address and the name of the group/department and coordinator to the system administrator. You will get a response within three working days.

When your IP address has been registered, you can connect to the server website: and download the client software from the Rosetta Resolver system.

Once the software has been successfully downloaded and installed on your PC, start the Rosetta Resolver client via Start >> Programs >> Rosetta Biosoftware >> Rosetta Resolver. The client will automatically connect to the server and you can log in with your user name and password.

If you can't locate the Rosetta Resolver client, look for it in the default installation location, which should be "C:\Program Files\Rosetta Resolver\Biosoftware\Resolver.exe". If you can't find it there, search the system for "Resolver.exe". If you can't find it this way, then the client is probably not installed (or not properly installed) on your computer.

User accounts [top][access]

All new users on the system need to be authenticated by their local coordinator. The minimum information required to register a user account is:

This information should be sent to your local coordinator for validation and authentication. Your coordinator will forward the information to the system administrators for registration.

After your information has been registered the system administrator will confirm this to the local coordinator, and you will in turn be informed by e-mail about the registration.

User accounts will be locked after 5 failing login attempts. Contact your local lab manager or coordinator to restore access. Users are not allowed to load patterns and their accounts will be locked if they try. Please ask your local manager or coordinator to load patterns and provide him with clear description of the array (contents and origin of the library on the array, array version and spotting date). Patterns of general commercially available arrays (Affymetrix, etc.), which should be available to many users, will be loaded by the administrator on request.

Keep your user name and password confidential!!!


Computer requirements [top][access]

The table below lists required components on Resolver client computers. We strongly encourage you to use the recommended requirements for best productivity.

CPU 800 MHz 1.4 GHz
Operating system Windows XP, Windows NT Workstation 4 with Service Pack 5, or Windows 2000 Windows XP, Windows NT Workstation 4 with Service Pack 5, or Windows 2000
Browser Microsoft Internet Explorer 5.0 Microsoft Internet Explorer 6.0 or higher
RAM 512 MB 1024 MB
Drive space available 50 MB 200 MB
Monitor 17 inch 21 inch
Pixels 1024 x 768 1280 x 1024
colors 65536 65536
Network speed 100-baseT 100-baseT

Database feature customization [top]

The Rosetta Resolver database comes with a number of standard options for species and experimental annotation. According to the users' needs, we can extend most of these. If you run into something you would like to have but do not find, please contact our administrators. Some examples:

General considerations [top]

When uploading profiles, please also keep a local back-up of your input files.

Tip when loading profiles [top]

Before you can load a profile, you NEED TO MAKE A CHIP BARCODE!!! Go to Chips in the Annotation tab and make all the New Chip Barcodes you need. Then select them when loading profiles. Optionally, you can also define Hybs and Preps in the Annotation tab, and add a lot of experimental annotation data to your Profile.

Loading Illumina data into Rosetta Resolver requires a correct preparation of the data files with Illumina BeadStudio. Instructions can be found here

Importing MAGE files
Unfortunately, MAGE file import via the Rosetta Resolver client does not work properly. Please ask your lab manager for help to load MAGE data. When pictures of the scans are to be included, make sure that their file name is exactly the same as that in the XML file. Your lab manager can request ftp access to the MAGE directory to import data using the AutoImporter.


Frequently Asked Questions [top]